Always consult with your doctor or other licensed medical professional. Do not delay seeking medical advice or disregard medical advice due to something you have read on this website.

  • From our own online cannabis marketplace , topicals only make up about 1% of all purchases.
  • Keep in mind that this product also contains menthol to aid in pain relief.
  • That being said, when compared with the other methods of consumption, topical applications lag far behind.
  • Even at just 1% of total purchases, topicals saw a 100% increase in popularity since the same time last year.

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However, it is not understood how these characteristics mediate the effects of THC outside of the entourage effect, and therefore requires further research. For example, in this study, researchers investigated the effects of orally consumed CBD on the effects of smoked THC.

Scientific and anecdotal evidence point to the conclusion that CBD can counteract the effects of THC, perhaps via the entourage effect. However, if life is to go on safely and economies are to survive, people may be willing to take the first treatment that arrives, CBD-based or not. However, the trials had to be canceled when these patients became unavailable and a number of other medical centers in Israel shut their coronavirus wards down due to a massive reduction in new cases. Other parties are exploring the potential for treating COVID-19 with cannabis, including Israeli canna-tech company Stero Therapeutics.

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It has become increasingly commonplace for recreational users to resort to CBD in the event of a ‘white-out’ (an unpleasant but harmless cannabis ‘overdose’). Recreational users report that this CBD oil works, which would create an unusual situation where CBD could be used by recreational cannabis users. As a result, anecdotal stories and recreational users remain some of the best sources of information regarding how CBD mediates the effects of THC. CBD is considered to be anti-psychotic and neuroprotective. This has implications for the application of CBD in certain mental illnesses such as bipolar, schizophrenia, dementia etc.

Most of THC-induced effects result from its partial agonist activity on receptors CB1 and CB2, respectively present mainly in the central nervous system and in the immune system. Its psychoactive properties, for instance, have to do with the former. CBD’s affinity for cannabinoid receptors is much weaker than THC, although it impacts the endocannabinoid system in other ways.

When oral CBD was administered, researchers observed no significant effect on any of the outcomes measured. This suggests that CBD’s effects on THC are due to individual differences in plasma drug levels. The entourage effect is something that generally refers to all the cannabinoids present in a single specimen of cannabis. Modern science is, as yet, unsure how the entourage effect translates into combining single cannabinoids that have already been isolated from the plant. There is much work to be done in terms of determining the exact details of how CBD interacts with CB1 and CB2 receptors, thus impacting the effects produced by THC.

However, CBD acts as a partial CB1 antagonist, and as a weak inverse CB2 agonist. CBD is considered to be anti-psychotic, and therefore can mediate the psychoactive effects of THC. But to what degree can this be proven in a lab, and to what extent can recreational users exploit this quality of CBD?

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